10 Best Best Folate And B12 Supplement of 2025

Tested and Reviewed: Top 10 Best Folate And B12 Supplement deals with expert ratings from 8.1 to a perfect 10

April 2026 Edition

Editor's Choice

9.7

Vital Nutrients

Vital Nutrients Vitamin B12 & Methyl Folate - Vegan Methylated Folate & B12 Supplement - 5-MTHF Plus B12 Supports Nervous System & Metabolism* - Gluten, Dairy, Soy Free - 100 Capsules

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Editor's bottom line:

“This best folate and b12 supplement is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Premium, Absorbable Methylated B Vitamins for GI & Nerve Health: This methylfolate supplement features B12 methylcobalamin and L-methylfolate in their most bioavailable forms. Methyl B12 and folate work together to support the gastrointestinal tract, nervous system, and overall wellness
High-Potency Support: Formulated with L-5-MTHF 800mcg, this methyl folate supplement for women provides essential support for pregnancy and overall health. Combined with vitamin B12 in its methylated B12 form, it helps promote energy, red blood cell formation, and nutrient absorption
Clean Vegan Formula. Hypoallergenic and Non-GMO. Made without artificial fillers, coatings, binders, or colors.
Quality You Can Rely on: Our rigorous quality assurance program includes third-party independent laboratory testing of raw ingredients and finished products for purity and potency to ensure whats on the label is in the bottle.
Trusted by Healthcare Practitioners Worldwide: Vital Nutrients was founded 30 years ago by practitioners who set out to make a positive and lasting impact on the health of people and planet. Today, our premium line of clinically relevant, pure, clean-label formulas is trusted by healthcare practitioners and health-conscious consumers worldwide.

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Picked by 397 people today

9.5

Triquetra Health

L Methyl Folate 15mg Plus Methyl B12 Cofactor – High Potency, Active 5-MTHF Form - Supports Mood, Methylation, Cognition – Bioactive Forms of Vitamin B9 & B12 (60 Capsules – 60 Servings)

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Main Highlights

HIGH-POTENCY: Provides a high-potency serving of 15mg L-Methylfolate in the 5-MTHF calcium salt form. This bioactive form of folate is readily utilized by the body.
VITAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships that work together in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.
ACTIVE FORM OF FOLATE: Methylfolate is the most metabolically active and bloodstream-ready form of Folate or Folic Acid (vitamin B9). It is immediately absorbed into the bloodstream because it does not require processing or breakdown by the body. This is vital for those with methylation issues that cannot properly process folic acid.
SUPPORTS BRAIN, MOOD & ENERGY HEALTH: Important for healthy neurotransmitter function linked to focus, energy, and a balanced mood.
SUPPORTS CARDIOVASCULAR, NITRIC OXIDE & NERVE HEALTH: Helps maintain healthy homocysteine levels, promotes normal heart function, and supports nitric oxide production for overall circulatory and nerve well-being.

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9.5

Triquetra Health

L Methyl Folate 15mg Plus Methyl B12 Cofactor – Organic Berry Flavor, High Potency Liquid Sublingual Active 5-MTHF Form - Supports Mood, Methylation, Cognition – Bioactive Forms Vitamin B9 & B12 (1oz)

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Main Highlights

HIGH-POTENCY: Provides a high-potency serving of 15mg L-Methylfolate in the 5-MTHF calcium salt form. This bioactive form of folate is readily utilized by the body.
VITAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships that work together in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.
ACTIVE FORM OF FOLATE: Methylfolate is the most metabolically active and bloodstream-ready form of Folate or Folic Acid (vitamin B9). It is immediately absorbed into the bloodstream because it does not require processing or breakdown by the body. This is vital for those with methylation issues that cannot properly process folic acid.
SUPPORTS BRAIN, MOOD & ENERGY HEALTH: Important for healthy neurotransmitter function linked to focus, energy, and a balanced mood.
SUPPORTS CARDIOVASCULAR, NITRIC OXIDE & NERVE HEALTH: Helps maintain healthy homocysteine levels, promotes normal heart function, and supports nitric oxide production for overall circulatory and nerve well-being.

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9.2

Life Extension

Life Extension BioActive Folate & Vitamin B12, Promotes Heart, Brain & GI Tract Health, Non-GMO, Gluten-Free, Vegetarian, 90 Capsules

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Main Highlights

Folate in the body 5-MTHF is the metabolically active form of folic acid and supports healthy DNA function, helps maintain normal homocysteine levels, and supports GI and immune function.
Benefits of vitamin B12 B12 is a vital member of the vitamin B family. The biologically active form of B12, methylcobalamin, supports cognitive health, nerve cell growth and metabolism.
The importance of vitamin B These two biologically active forms of B9 and B12 ensure that you are covering your bases and getting the many benefits of these forms of vitamin B.
Ingredients matter We use the finest raw ingredients chosen for quality and purity. The majority of our products are non-GMO, gluten-free and manufactured in the USA with globally sourced ingredients, and a Certificate of Analysis is available for each.
Live your healthiest life We believe the answers to a healthier life are in reach, and that scientific research is the key to getting there. Thats why so many of our formulas feature specific ingredients and amounts based on scientific studies.

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9.0

Pure Encapsulations

Pure Encapsulations B12 Folate - Energy Supplement to Support Nerves, Energy Metabolism & Cognitive Support* - with Vitamin B Folate as Metafolin - 60 Capsules

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Main Highlights

Premium Folate Supplement: Vitamin B12 and folate help convert carbohydrates into energy and break down proteins in the body; provides metabolism support*
Nervous System Support: Vitamin B12 (methylcobalamin) and folate (L-5-MTHF) support the nervous system, and function as hair, skin, and liver aids.*
Cognitive Support: Folate is essential for fetal neural development; B12 is an important nutrient for memory and cognitive support*
Supports Gut Health: Support G.I. tract thanks to the active form of the B12 vitamin, methylcobalamin; also a liver support supplement*
Pure Difference: What we leave out matters, too; Pure Encapsulations products are free from common allergens, artificial or unnecessary ingredients, and GMOs

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8.8

Jarrow Formulas

Jarrow Formulas Methyl B-12 & Methyl Folate, Bioactive Vitamin B9 & Vitamin B12 Supplement, Supports Cellular Energy Production, Healthy Brain Function & Metabolism, 100 Chewable Tablets, 100 Servings

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Main Highlights

Cellular Energy Metabolism and Cardiovascular support supplement: Contains one 100 count bottle of Jarrow Formulas Extra Strength Methyl B-12 1000 mcg & Methyl Folate 400 mcg Chewable Tablets for a 100-day supply.
Offers a unique combination of B Vitamins in easy-to-take, lemon-flavored chewable tablets to support cellular energy metabolism, neurotransmitter synthesis and cardiovascular health.
Dietary supplement with Methyl B12, Methyl Folate and Pyridoxal-5-Phosphate (P-5-P), the active forms of Vitamins B-12, B9 and B6.
Suggested Use: Adults, take one chewable tablet once a day or as directed by your qualified healthcare professional.
These statements have not been evaluated by the Food and Drug Administration; this product is not intended to diagnose, treat, cure, or prevent any disease.

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8.6

Nutricost

Nutricost Methylated Vitamin B12 + Folate Supplement (2,000 mcg) 120 Capsules - 1,000 mcg of Vitamin B12 + 1,000 mcg of Methyl Folate, Gluten-Free, 60 Servings

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Main Highlights

Methylated Formula Each serving provides 1,000mcg of methylated Vitamin B12 (methylcobalamin) and 1,000mcg of methyl folate (Vitamin B9)
Generous Supply 120 easy-to-swallow capsules per bottle
Added Support Includes 30mg of calcium per serving
Quality Choice Gluten-free and made with high standards
Manufactured in an NSF Certified, GMP Compliant, FDA Registered Facility

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8.3

Jarrow Formulas

Jarrow Formulas Methyl B-12 & Methyl Folate, Bioactive Vitamin B9 and Vitamin B12 Supplement, Supports Cellular Energy Production, Healthy Brain Function & Metabolism, 60 Chewable Tablets, 60 Servings

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Main Highlights

Cellular Energy Metabolism and Cardiovascular support supplement: Contains one 60 count bottle of Jarrow Formulas Ultra Strength Methyl B-12 5000mcg & Methyl Folate 800mcg Chewable Tablets for a 60-day supply.
Easy-to-take, cherry-flavored chewable tablets to support your cardiovascular health and cellular energy production.
Dietary supplement with a high amount of Methyl B-12, Methyl Folate and Pyridoxal-5-Phosphate (P-5-P), the active forms of Vitamins B-12, B9 and B6.
Suggested Use: Adults, take one chewable tablet once a day or as directed by your qualified healthcare professional.
These statements have not been evaluated by the Food and Drug Administration; this product is not intended to diagnose, treat, cure, or prevent any disease.

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8.1

aSquared Nutrition

aSquared Nutrition L Methylfolate Plus Methyl B12 - Methylated Folate Supplement for Women & Men - 5-MTHF (Active Vitamin B9) 1000 mcg & B-12 1mg - B Complex - 60 Capsules

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Main Highlights

Active Folate + Methyl B12 Support: Each serving delivers 1,700 mcg DFE folate from L-5-MTHF (1,000 mcg L-methylfolate) plus 1,000mcg methylcobalamin B12 to support cellular function, support healthy red blood cell production, and nervous system health. A clean, high-utility methylated B vitamin blend for daily wellness routines. *
Synergistic B-Vitamin Cofactors: Includes riboflavin-5-phosphate (R5P) 5 mg, the active form of vitamin B2, to support nutrient metabolism and the bodys ability to utilize folate and B12 efficiently. Thoughtfully balanced formula built for consistent daily use, with targeted ingredients people look for in methylfolate supplements. *
Added TMG for Methyl Support: Features 250 mg betaine anhydrous (TMG) per serving, a methyl donor that supports healthy homocysteine levels already within a normal range and supports overall cellular processes. Ideal for those seeking an active folate + B12 complex with complementary methyl donor support and modern, research-driven ingredient choices. *
Clean, Vegan Capsules: Vegan friendly capsules with no unnecessary extras, designed for easy daily supplementation. A simple, effective methylfolate and methyl B12 capsule supplement that fits a variety of wellness goalsenergy metabolism support, cognitive and nerve support, and everyday nutritional coveragewithout complicated dosing or powders. *
Quality You Can Trust: Made in a GMP compliant facility and third-party tested for potency and purity, so you can feel confident in every bottle. Premium active folate (L-5-MTHF), methylcobalamin B12, R5P riboflavin, and TMG betainecarefully measured, clearly labeled, and produced with high standards for consistency. *

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8.1

THORNE

THORNE - B-Complex #12 - Vitamin B Complex with Active B12 and Folate - 60 Capsules

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Main Highlights

Complete Formula: Each capsule provides an optimized balance of 8 water-soluble B vitamins (B1, B2, B3, B5, B6, B12, folate, and biotin) plus choline
Nerves and Brain: Formulated with extra vitamin B12 to support healthy nerve cells and an optimally functioning nervous system*
Methylated Vitamins: Provides the active, methylated forms of vitamin B12 (as methylcobalamin) and folate (as 5-MTHF), in a formula that supports cellular repair processes*
3rd Party Contents Certified: This product has been third-party tested and certified to verify what's in the package matches what's on the label
Trusted: Thorne is chosen by champions and trusted by 100+ professional sports teams, a proud partner of U.S. National Teams, and the #1 recommended clinical brand by health-care practitioners (2023 Health-Care Practitioner Seller Survey)

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Our Best Overall Choice

Best Choice

9.7

Vital Nutrients

Vital Nutrients Vitamin B12 & Methyl Folate - Vegan Methylated Folate & B12 Supplement - 5-MTHF Plus B12 Supports Nervous System & Metabolism* - Gluten, Dairy, Soy Free - 100 Capsules

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Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Premium, Absorbable Methylated B Vitamins for GI & Nerve Health: This methylfolate supplement features B12 methylcobalamin and L-methylfolate in their most bioavailable forms. Methyl B12 and folate work together to support the gastrointestinal tract, nervous system, and overall wellness
High-Potency Support: Formulated with L-5-MTHF 800mcg, this methyl folate supplement for women provides essential support for pregnancy and overall health. Combined with vitamin B12 in its methylated B12 form, it helps promote energy, red blood cell formation, and nutrient absorption
Clean Vegan Formula. Hypoallergenic and Non-GMO. Made without artificial fillers, coatings, binders, or colors.
Quality You Can Rely on: Our rigorous quality assurance program includes third-party independent laboratory testing of raw ingredients and finished products for purity and potency to ensure whats on the label is in the bottle.
Trusted by Healthcare Practitioners Worldwide: Vital Nutrients was founded 30 years ago by practitioners who set out to make a positive and lasting impact on the health of people and planet. Today, our premium line of clinically relevant, pure, clean-label formulas is trusted by healthcare practitioners and health-conscious consumers worldwide.

Show Price

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