10 Best Best Fluoride Toothpaste of 2025

Tested and Reviewed: Top 10 Best Fluoride Toothpaste deals with expert ratings from 8.1 to a perfect 10

March 2026 Edition

Editor's Choice

9.7

Boka

Boka Fluoride Free Toothpaste, Nano Hydroxyapatite Toothpaste, Appropriate for Sensitive Teeth - for Adult Oral Care - Ela Mint Flavor, 4 Fl Oz 1Pk US Manufactured

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Editor's bottom line:

“This best fluoride toothpaste is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

ENAMEL CARE: Our proprietary and innovative formula includes Nano-hydroxyapatite (n-Ha) - a biomimetic mineral form of the same ingredient that naturally makes up 97% of your enamel and 70% of your dentin. n-Ha has been the subject of significant research for decades with a wide variety of potential benefits across dentistry and oral care.
FLUORIDE-FREE: Gentle for daily use as directed, our nano hydroxyapatite toothpaste is science-backed and nature-inspired. Regular brushing supports enamel care without fluoride.
LIGHT AND LOW-FOAMING: A soft, creamy texture that keeps brushing comfortable from start to finish.
MINTY FRESH: We complemented n-Ha with our soothing aloe vera, xylitol, green tea, and refreshing mint, to give this paste a refreshing and invigorating flavor profile.
WE KEEP IT SIMPLE: No Fluoride, Sulfates, Parabens, or Artificial Colors. Offering you an effective toothpaste option manufactured in the US from domestic and imported materials.

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Picked by 397 people today

9.5

Made by Dentists

Made by Dentists Professional Enamel Rebuilding Toothpaste - 2 Pack - Remineralizing Nano Hydroxyapatite Toothpaste with Sodium Fluoride, ADA Approved, Vegan, 2 x 4.2oz

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Main Highlights

ADVANCED ENAMEL REBUILDING: Our nano hydroxyapatite toothpaste with fluoride combines hydroxyapatitethe natural mineral that makes up 97% of enamelwith fluoride to remineralize and strengthen teeth. Made By Dentists hydroxyapatite-based formula helps protect against cavities and everyday wear for a healthier smile.
HOW IT WORKS: Everyday eating and drinking lowers mouth pH, which weakens enamel. Made By Dentists toothpaste with nano-hydroxyapatite penetrates deep into teeth to restore lost minerals from within, supporting strong, cavity-resistant enamel.
PROTECTS AGAINST SENSITIVITY: Our adult remineralizing toothpaste is formulated with potassium nitrate to relieve sensitivity by blocking pathways to nerves, while strengthening enamel to prevent future discomfort.
ADA Approved: Made By Dentists is officially recognized by the American Dental Association for safe and effective whitening and sensitivity protection. Our remineralizing toothpaste with hydroxyapatite also contains fluoride to help prevent cavities.
VEGAN, CRUELTY-FREE, & ECO-FRIENDLY: A natural hydroxyapatite toothpaste with enamel-safe ingredients, crafted by dentists. Packaged in 100% recyclable materials, making it a natural remineralizing toothpaste that supports both oral health and the planet.

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9.5

biotène

biotène Fluoride Toothpaste for Dry Mouth Symptoms, Bad Breath Treatment and Cavity Prevention, Fresh Mint - 4.3 oz

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Main Highlights

One 4.3 oz tube of Biotene Fluoride Toothpaste for Dry Mouth Symptoms and Bad Breath, Fresh Mint
Non-irritating toothpaste ideal for those experiencing dry mouth symptoms
Fluoride helps protect against cavities and strengthen teeth for enhanced oral health
Sugar free and alcohol free toothpaste that's an effective breath freshener
Mint flavored toothpaste that refreshes your mouth
HOW TO USE: Use Biotène Fresh Mint Original Fluoride Toothpaste at least twice a day to help protect against cavities and freshen your breath.

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9.2

Crest

Crest + Scope Whitening Toothpaste - Pack of 3, 5.4 Oz Tubes - Anticavity Fluoride Toothpaste, Fresh Breath, Kills Germs - Tartar Protection, Enamel Protection - Minty Fresh Flavor

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Main Highlights

BULK TOOTHPASTE: Includes three 5.4 oz cartons of Crest + Scope Whitening Toothpaste.
BAD BREATH KILLER: Our Crest toothpaste kills millions of bad breath germs in laboratory tests, ensuring your oral hygiene.
CAVITY AND TARTAR FIGHTER: Fights cavities and tartar, strengthening enamel with our fluoride toothpaste.
WHITENING TOOTHPASTE: Gently removes surface stains for whiter teeth, making it an excellent choice for enamel safe whitening.

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9.0

3M

3M 70201400788 OMNI Gel Brush-On Fluoride, 0.4% Stannous Fluoride, Extra Cavity Protection, Use After Toothpaste, Mint, 4.3 oz

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Main Highlights

EXTRA CAVITY PROTECTION for people who have a history of cavities, as well as those living in areas with less-than-optimal fluoride levels in their drinking water
EASY TO APPLY: Brush-on fluoride gel is simply applied once a day after you brush your teeth with toothpaste
PROVEN EFFECTIVENESS: 0.4% stannous fluoride has been proven to be very effective in the fight against decay
RECOMMENDED BY DENTAL PROFESSIONALS as a home care treatment to help prevent cavities
FLUORIDE IS A NATURALLY OCCURRING, beneficial mineral that holds onto calcium and phosphate (the building blocks of teeth) in the mouth, which increases the remineralization of weak enamel
For patients who prefer a brush-on fluoride treatment
Proven therapeutic provides caries reduction
Enhanced re-mineralization

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8.8

TheraBreath

TheraBreath Healthy Gums Toothpaste, Fights Bad Breath for 12 Hours, with Stannous Fluoride for Anticavity & Gingivitis Protection, Clean Mint, 4 Oz, 2-Pack

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Main Highlights

A pack of two 4 oz TheraBreath Healthy Gums Toothpaste; Clean Mint flavor is long-lasting for epic freshness
Reduces gumline plaque for 24 hours to protect against gingivitis (1); helps prevent tooth decay and interferes with the harmful effects of plaque associated with gingivitis
Helps fight morning breath and neutralizes the source of bad breath (3); gently whitens even sensitive teeth while staying kind to enamel with no harsh abrasives
Dentist-formulated and proudly made in the USA with U.S. and internationally sourced ingredients; certified vegan, halal, gluten-free, and kosher
From the Best-Selling Alcohol-Free Mouthwash Brand in the USA (2); Mix and match with your favorite TheraBreath Oral Rinse to power up your routine

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8.6

Crest

Crest Pro-Health Gum Detoxify Plus Toothpaste 4.5 oz Pack of 3 - Antibacterial Fluoride Toothpaste, Sensitivity Protection, Whitens Teeth, Anticavity, Plaque Control

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Main Highlights

You will receive (3) 4.5 oz tubes of Crest Gum Detoxify Plus.
NEUTRALIZES PLAQUE BACTERIA, even around the gumline, for 24 hours when using twice daily.
SENSITIVITY PROTECTION with the power of stannous fluoride.
WHITENS teeth.
HELPS HEAL GUMS AND STOP BLEEDING.
CLINICALLY PROVEN to fortify gums to protect teeth by helping reverse gingivitis.
PREVENTS HARMFUL OXIDANTS from causing stress on the gums.
#1 GUM TOOTHPASTE BRAND in America & #1 TOOTHPASTE BRAND in America. (P&G calculation based on U.S. reported sales data for the year ending w/o 1/27/2024)

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8.3

hello

hello Naturally Whitening Fluoride Toothpaste, Natural Whitening Toothpaste with Coconut Oil and Tea Tree Oil, Tames Bad Breath, Helps Moisturize, and Fights Cavities, Mint, 3 Pack, 4.7 Oz Tubes

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Main Highlights

WHAT I'M GETTING: Includes three (3) 4.7 oz tubes of hello Naturally Whitening Fluoride Toothpaste, Mint
SEE YA STAINS: Whitens naturally with natural whitening ingredients to remove surface stains and uses fluoride to help prevent cavities and strengthen teeth enamel
SO FRESH: This naturally whitening toothpaste is formulated with super-peppy peppermint so you can experience mind-blowing freshness every time you brush
NO-BRAINER: This hello whitening toothpaste is peroxide free, SLS free, and has no artificial sweeteners or flavors, no dyes, no parabens, and no titanium dioxide
EVERYDAY YAY: hello Naturally Whitening Fluoride Toothpaste is a vegan toothpaste and is not tested on animals

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8.1

Sensodyne

Sensodyne Toothpaste Sensitivity Gum and Enamel, Triple Protection, Refreshing Fluoride Toothpaste, Mint Flavor - 3.4 Ounces x 3

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Main Highlights

Three 3.4 oz tubes of Mint flavored Sensodyne Toothpaste Sensitivity Gum and Enamel, Triple Protection, Refreshing Fluoride Toothpaste
Toothpaste for sensitive teeth from the number 1 dentist-recommended toothpaste brand for sensitive teeth
Sensodyne Sensitivity Gum and Enamel Toothpaste is clinically proven to provide long-lasting sensitivity protection and to help restore gum health while rehardening the enamel
Sensitivity toothpaste strengthens the enamel surface and protects teeth from acids while feeling gentle on gums, for strong, healthy teeth and dental care
Targets and removes plaque bacteria to fight gingivitis & improve gum health

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8.1

Colgate

Colgate Cavity Protection Toothpaste with Fluoride, Minty Great Regular Flavor, Anti Cavity Toothpaste, 6 Pack, 6 Oz Tubes

Free Shipping

Main Highlights

This 6 pack of Colgate Cavity Protection fluoride toothpaste fights cavities
This anti cavity toothpaste cleans teeth thoroughly, for a cleaner mouth feel
Strengthens teeth enamel with active fluoride, a key ingredient that helps prevent tooth decay and cavities
Great mint taste ensures your mouth stays minty fresh every time you brush with this anticavity toothpaste
Protect your teeth from harmful cavities using this cavity protection toothpaste

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Our Best Overall Choice

Best Choice

9.7

Boka

Boka Fluoride Free Toothpaste, Nano Hydroxyapatite Toothpaste, Appropriate for Sensitive Teeth - for Adult Oral Care - Ela Mint Flavor, 4 Fl Oz 1Pk US Manufactured

Free Shipping

Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

ENAMEL CARE: Our proprietary and innovative formula includes Nano-hydroxyapatite (n-Ha) - a biomimetic mineral form of the same ingredient that naturally makes up 97% of your enamel and 70% of your dentin. n-Ha has been the subject of significant research for decades with a wide variety of potential benefits across dentistry and oral care.
FLUORIDE-FREE: Gentle for daily use as directed, our nano hydroxyapatite toothpaste is science-backed and nature-inspired. Regular brushing supports enamel care without fluoride.
LIGHT AND LOW-FOAMING: A soft, creamy texture that keeps brushing comfortable from start to finish.
MINTY FRESH: We complemented n-Ha with our soothing aloe vera, xylitol, green tea, and refreshing mint, to give this paste a refreshing and invigorating flavor profile.
WE KEEP IT SIMPLE: No Fluoride, Sulfates, Parabens, or Artificial Colors. Offering you an effective toothpaste option manufactured in the US from domestic and imported materials.

Show Price

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