10 Best Best Eye Drops For Severe Dry Eyes of 2025

Tested and Reviewed: Top 10 Best Eye Drops For Severe Dry Eyes deals with expert ratings from 8.1 to a perfect 10

July 2025 Edition

Editor's Choice

9.7

Save 43%

Systane

Systane COMPLETE PF Multi-Dose Preservative Free Dry Eye Drops 0.34 Fl Oz, 2 count (pack of 1) (Packaging may vary)

43% OffFree Shipping

Editor's bottom line:

“This best eye drops for severe dry eyes is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Fast acting hydration for sensitive eyes
Preservative free tear evaporation protection
Nano droplets for better coverage

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Picked by 239 people today

9.5

Save 17%

Systane

Systane Pro PF Dry Eye Relief Preservative Free Lubricant Eye Drops 10 mL

17% OffFree Shipping

Main Highlights

Triple-Action Dry Eye Relief: Systane Pro Preservative Free Eye Drops hydrate, restore and protect dry eyes for long-lasting relief
Long-Lasting Hydration: Systane Pro Preservative Free lubricating eye drops are formulated with Hyaluronate, a moisturizer that occurs naturally in tears, to support extended hydration
Tear Evaporation Protection: This unique formula enhanced with lipid nanodroplets provides superior tear evaporation protection versus other leading drops^
Preservative-Free Formula: The gentle, preservative-free formula is ideal for sensitive eyes
Trusted Brand: Systane is a trusted name in eye care, recommended by eye care professionals for its effective and reliable relief
Convenient Size: The 10mL oz bottle is perfect for daily use, offering you triple action dry eye relief at your fingertips
Contact Lens Friendly*: safe for use with soft contact lenses

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9.5

Save 17%

Refresh

Refresh Optive MEGA-3 Lubricant Eye Drops Preservative-Free Artificial Tears, 0.01 fl oz (0.4 mL), 30 Single-Use Containers

17% OffFree Shipping

Main Highlights

FAST-ACTING: Rapid relief to comfort dry, irritated eyes
LASTING RELIEF: Soothes and prevents further irritation
TRIPLE-ACTION FORMULA: Lubricates, hydrates, and protects tears from evaporating
PRESERVATIVE-FREE: Enhanced with antioxidants and plant-based Flaxseed Oil (inactive ingredients) which contains omega-3s
ADVANCED HYDRATION: Innovated with patented HydroCell technology that enables rehydration
ON-THE-GO VIALS: 30 sterile single-use vials per carton that are easy and safe to use as often as needed
TRUSTED: From the #1 doctor-recommended preservative-free brand with over 35 years of experience (Data on file, AbbVie, Inc. REF113774)
FSA & HSA ELIGIBLE: Your pre-tax dollars may cover this product as an out-of-pocket expense depending on your plan

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9.2

Save 9%

Systane

Systane Ultra Lubricant Eye Drops, Artificial Tears for Dry Eye, Twin Pack, 10-mL Each

9% OffFree Shipping

Main Highlights

#1 Dr Recommended Brand of Artificial Tears*, packaging may vary
Extended Protection
Fast Long-Lasting Dry Eye Symptom Relief.Store at room temperature
Reduces both the signs and symptoms of dry eye
Quickly soothe irritated eyes wherever you are

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9.0

Save 7%

Refresh

Refresh Tears, Lubricant Eye Drops, 2 Bottles .5 fl oz (15 ml)

7% OffFree Shipping

Main Highlights

IMMEDIATE DRY EYE RELIEF: Quickly alleviates dryness, irritation, and discomfort by replenishing moisture to the eyes.
MIMICS NATURAL TEARS: Formulated to closely resemble natural tears, providing soothing and effective hydration.
CONTACT LENS COMPATIBLE: Safe for use with contact lenses, making it convenient for individuals with corrective eyewear.
GENTLE DAILY FORMULA: Non-irritating and suitable for frequent use to maintain eye comfort throughout the day.
PROTECTIVE MOISTURE BARRIER: Helps shield eyes from further dryness and irritation caused by environmental factors.

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8.8

Save 35%

TheraTears

TheraTears Extra Dry Eye Therapy Lubricating Eye Drops for Dry Eyes, 0.5 fl oz Bottle, 2 Count(Pack of 1)

35% OffFree Shipping

Main Highlights

Get up to 12 Hours of Hydrating Comfort; TheraTears EXTRA Dry Eye Therapy Lubricant Eye Drops provide EXTRAordinary relief for dry eyes
Discover TheraTears eye drop; one-of-a-kind silky hydration for dry eyes
Lubricating eye drops for extra dry eyes rehydrate; protect against further irritation and support a natural tear pH level
TheraTears Extra Dry Eye lubricating eye drops contain the 5 vital electrolytes found in natural tears
TheraTears corrects the salt imbalance that can cause dry eye symptoms
Doctor recommended and created; TheraTears was created by an ophthalmologist after 18 years of research
Contains 2 bottles of TheraTears EXTRA Dry Eye Therapy Lubricant Eye Drops, 0.5 fl oz
FSA- and HSA-eligible product in the U.S.

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8.6

Save 12%

BLINK

Blink Eye Drops for Dry Eyes, Triple Care Lubricant Eye Drops, Instantly Soothing, Moisturizing & Extra Long-Lasting Hydrating Eye Care for Moderate to Severe Dry Eye Symptom Relief, 0.34 fl oz

12% OffFree Shipping

Main Highlights

Relief with every Blink: Experience extended dry eye symptom relief with Blink Triple Care Lubricating Eye Drops. This 3-in-1 formula instantly soothes, gives extra long-lasting hydration, and seals in moisture.
Dry Eye Lubricant: Discover what makes Blink Triple Care Lubricating Eye Drops different from other eye drops. Our drops for dry eyes have a dual-action moisture seal to lock in moisture for instant, long-lasting relief.
Long-Lasting Hydration: Blink Triple Care Lubricating Eye Drops are formulated with hyaluronate - also found in your eyes - to boost hydration. Hydrate like your tears for extra long-lasting comfort
Reduce Everyday Discomfort: These dops for dry eyes deliver extended relief for moderate to severe dry eye symptoms
Trusted Brand: Blink has a range of products to meet your eye and contact lens care needs, from drops for dry eyes to lock in moisture, to preservative-free formulas; and contact lens drops to keep your contacts clean and hydrated.

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8.3

Biotrue

Biotrue Hydration Boost Eye Drops, Preservative Free, Soft Contact Lens Friendly for Irritated and Dry Eyes from Bausch + Lomb, Naturally Inspired, 0.33 FL OZ (10 mL)

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Main Highlights

NATURALLY INSPIRED INGREDIENTS: Biotrue Hydration Boost Eye Drops are enhanced with HA (Hyaluronan), Antioxidant, and Electrolyte and provide instant moisture for dry eyes.
CONTACT LENS FRIENDLY: Biotrue Hydration Boost Eye Drops can be applied while wearing soft contact lenses.
INSTANT MOISTURE: For dry, irritated eyes due to screen and environmental stressors.
BIOTRUE EYE DROPS: Not only are the Hydration Boost Eye Drops free of preservatives but they are also pH balanced.
EYE DROPS and MORE: Bausch and Lomb makes eye care products you can trust, from contact lens solution to eye drops, vitamins, and ointments to help your eyes feel moisturized and protected.

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8.1

Save 16%