10 Best Best Butyrate Supplement of 2025

Tested and Reviewed: Top 10 Best Butyrate Supplement deals with expert ratings from 8.1 to a perfect 10

October 2025 Edition

Editor's Choice

9.7

Tesseract Medical Research

Tesseract Medical Research ProButyrate Gut Health Supplement, Butyric Acid Complex, Gastrointestinal Support Supplement, Helps Restore Balance to Stabilize Gut Microbiome, 600mg, 120 Capsules

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Editor's bottom line:

“This best butyrate supplement is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Revolutionary Digestive Health Supplement: ProButyrate is formulated with Butyric Acid in a sustained-release format, unlike other supplements that use Butyric salts, such as Sodium Butyrate. This palatable butyric acid supplement helps promote a healthy gut*
Maximum Absorption for Gut Health Support: Butyric acid is a short-chain fatty acid that supports the health of the gastrointestinal tract.* Insufficient natural production of this important fatty acid often leads to unpleasant adverse digestive conditions
Unrivalled Delivery: Tesseracts proprietary nano-molecular delivery science results in optimal absorption and bioavailability at micro-doses. A ground-breaking transport and time-release system that enables you to receive the full health benefits from your dietary supplements
Radically Advanced Formulation: Our CyLoc technology encases every nano-molecule of active ingredient in a unique carrier, and pairs it with the DexKey release agent. This allows for maximum absorption and efficacy of natural clinically researched nutrients
The Power of Tesseract: Tesseract Medical Research uses advanced scientific technology to make potent, breakthrough dietary supplements and medical foods to support optimum neurological, musculoskeletal, immune, and GI health.* Revolutionize your health with the full impact of clinically researched nutrients

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Picked by 308 people today

9.5

Designs for Health

Designs for Health Tri-Butyrin Supreme - 3-in-1 Butyric Acid (Butyrate) Postbiotics for Gut Health & Gut Permeability Support - Tributyrin Supplement with Odor-Minimizing Innovation (60 Softgels)

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Main Highlights

Why Take A "Post-Biotic" For GI Health? Gut health doesn't stop with pre- and probiotics. Complete your GI health regimen with Butyrate, a beneficial compound that may help maintain intestinal flora and promote colon health.*
Immune Support - The gut is a primary player in the immune system. By supporting the gut lining, butyrate contributes to healthy immune function.*
Targeted, Triple Butyrate - Tributyrin is a unique fusion of three butyrate molecules attached to glycerol.*
Always Pure & Effective Products - This product is formulated without gluten.*
Clinically-Trusted Care - DFH is the #1 practitioner supplement brand recommended by functional medicine professionals and the #1 practitioner supplement brand personally trusted by functional medicine professionals.**

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9.5

BodyBio

BodyBio Sodium Butyrate - Postbiotic for Gut Health, Leaky Gut Repair, Digestive Support, Bloating Relief, & Microbiome Balance - Butyric Acid Supplement for GI Wellness

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Main Highlights

Gut Health & Microbiome Support: Bodybio Butyrate is a powerful postbiotic that is designed to nourish and protect the gut lining, support healthy digestion, and help maintain optimal gut microbiome balance.*
Digestion & Bloating Support: Butyrate promotes healthy, regular bowel movements while supporting digestive efficiency to help reduce gas, bloating, and post-meal discomfort.*
Leaky Gut Repair: Butyrate helps strengthen the gut lining and supports a healthier barrier, keeping toxins out and nutrients in for better overall gut health.*
No Fillers or Additives vegan capsules: We do not use fillers or additives to mask the scent of Butyrate. We create butyrate exactly as its formed in the colon. All natural ingredients and free of wheat, gluten, yeast, corn, soy, dairy, artificial colors, and resins.
Third Party Tested: Every batch undergoes extreme testing: first in our in-house lab, then again by certified third-party facilities that meet strict cGMP standards.

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9.2

BodyBio

BodyBio Calcium Magnesium Butyrate - Postbiotic for Gut Health, Leaky Gut Repair, Digestive Support, Bloating Relief, & Microbiome Balance - Butyric Acid Supplement for GI Wellness

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Main Highlights

Gut Health & Microbiome Support: Bodybio Butyrate is a powerful postbiotic that is designed to nourish and protect the gut lining, support healthy digestion, and help maintain optimal gut microbiome balance.*
Digestion & Bloating Support: Butyrate promotes healthy, regular bowel movements while supporting digestive efficiency to help reduce gas, bloating, and post-meal discomfort.*
Leaky Gut Repair: Butyrate helps strengthen the gut lining and supports a healthier barrier, keeping toxins out and nutrients in for better overall gut health.*
No Fillers or Additives vegan capsules: We do not use fillers or additives to mask the scent of Butyrate. We create butyrate exactly as its formed in the colon. All natural ingredients and free of wheat, gluten, yeast, corn, soy, dairy, artificial colors, and resins.
Third Party Tested: Every batch undergoes extreme testing: first in our in-house lab, then again by certified third-party facilities that meet strict cGMP standards.

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9.0

Quorinthiumax

Tributyrin Supplement for Gut & Immune 800mg | High Bioavailability with Microencapsulated Probiotics & Prebiotics - Advanced Liquid-Filled Tributyrin Complex, Gluten Free, 90 Capsules

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Main Highlights

High-Potency Tributyrin Formula: Tributyrin, a well-researched form of butyric acid, known for its targeted role in dietary supplementation. Each serving provides 800mg of Tributyrin, carefully crafted for a concentrated and effective addition to your daily routine
Innovative Microencapsulation Technology: Using advanced microencapsulation technology, our probiotic prebiotic supplement shields active ingredients and ensures precise delivery to the gut, maximizing absorption and bioavailability. This method preserves the integrity and potency of probiotics and prebiotics
Probiotic & Prebiotic Complex: Combining 10 billion CFU of probiotics with 150 mg of prebiotic fiber, this tributyrin gut supplement is designed for ingredient synergy. The probiotics and prebiotics work together to ensure optimized delivery and efficient interaction, supporting a well-rounded supplement experience
Scientific Synergistic Ingredient: This tributyrin prestbiotic supplement combines Curcumin, Black Cumin Seed Oil, Algal Oil, and Ginger Extracteach carefully chosen for its unique properties, collaborating with each other for overall well-being
Easy-to-Swallow Tributyrin Capsules: Unlike traditional tributyrin capsules, our tributyrin capsule supplement uses cutting-edge liquid-filled capsules that deliver potent ingredients more efficiently, making them easier on the stomach and quicker to absorb while preserving freshness with a secure seal

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8.8

LongJuvity Labs

LongJuvity Sodium Butyrate Supplement (300mg) - Naturally Sourced Postbiotic - Optimal Gut Health & Leaky Gut Repair - Postbiotic Short Chain Fatty Acid, Lab Tested (120 Extended Release Caps)

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Main Highlights

SUPPORTS GUT HEALTH FOR WOMEN & MEN: LongJuvity Sodium Butyrate helps strengthen the intestinal barrier to protect against leaky gut, keeping your digestive system strong and resilient. It promotes a balanced microbiome by nourishing beneficial bacteria and reducing gut imbalances.
EXTENDED RELEASE MICRO-GRANULE FORMULA: Designed with advanced micro-encapsulation technology, each 300mg butyrate acid capsule delivers sodium butyrate directly to the lower gastrointestinal tract, maximizing absorption where it counts.
ESSENTIAL FUEL FOR COLON CELLS & NUTRIENT ABSORPTION: Acts as a vital energy source for colon cells, improving nutrient absorption, bloating, and promoting overall better balanced digestive health. It also supports fluid and electrolyte absorption, helping maintain hydration and electrolyte balance.
MORE THAN JUST GUT HEALTH: Beyond digestion, sodium butyrate provides powerful antioxidant benefits and functions as an HDAC inhibitor, contributing to cellular health, gene regulation, and overall body wellness.
NATURALLY SOURCED & LAB TESTED FOR QUALITY: Our Sodium Butyrate gut health supplement is made from high-quality, naturally sourced ingredients and independently lab-tested for purity, so you can trust you're getting a premium product without unnecessary additives.

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8.6

Nextdia

Butyrate Gummies with Probiotic + Prebiotic + Postbiotic, Omega-3 500mg,Fiber with 9 Billion CFU Probiotics, Calcium & Magnesium, Inulin,Psyllium Husk for Digestive Health,Bloating Support,Sugar Free

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Main Highlights

[Unique Sugar-Free Liquid Filled Gummies] The delicious 3 in 1 pro+pre+postbiotic gummies feature a gelatin-free chewy outer layer and a natural peach-flavored filling. Adopting advanced GummieJel Technology that encapsulates active ingredients butyrate, calcium & magnesium, which are sensitive to temperature/pH, to ensure maximum potency and stability. Additionally, it wraps lipophilic nutrients Omega-3 and prebiotic fiber, making nutrition easier to absorb.
[Miraculous Postbiotic-Butyrate with Calcium & Magnesium Complex] Butyrate fuels beneficial bacteria growth and supports microbial balance. It aids in transporting nutrients to tissues & organs, expels harmful substances. Ca regulates muscle contractions while mag relaxes muscles in the gut. Both are essential minerals for gut. Butyrate forms complex with the easily soluble ca and mag, increasing bioavailability, maximizing support bloating, promoting bowel movements & nutrient absorption.
[9 Billion CFU Probiotic & Chewy Prebiotic Fiber] Nextdia prebiotic fiber gummies are fortified with 9 Billion CFU probiotics-L. acidophilus, L. rhamnosus. These probiotics work together to maintain microbiota balance and support nutrient absorption. The added fibers - inulin & psyllium husk - form a gel-like substance in the digestive tract, promoting feelings of fullness and satiety.This helps in eating less, facilitates regular bowel cleansing, and aids in achieving your goals faster.
[Sustainable and Cleaner omega-3 for Digestive Health] Algae-derived Omega-3 fatty acids support gut barrier and health by reducing gut permeability, exerting prebiotic effects that promote beneficial bacteria growth while restraining harmful bacteria. Butyrate and Omega-3 fatty acids complementarily modulate the gut microbiota, synergistically strengthening the intestinal barrier and fostering a healthy gut environment.
[Great for Men and Women] Sugar free filled gummies are designed for both men and women. Take 2 gummies per day. The delicious peach flavor tastes great and is easy to chew. The gummies are gluten-free, soy-free, wheat & yeast-free, 100% vegan and NON-GMO. 3rd-Party Tested, made in USA. Please feel free to contact us with any questions.

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8.3

Vita Bloom Labs

CoreBiome Tributyrin Supplement - Better Delivery & More Effective than Sodium Butyrate - Gut Health & Digestive Support - 3-in-1 Butyrate Postbiotics for Leaky Gut & Gut Barrier Support - 30 Capsules

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Main Highlights

NEXT GENERATION POSTBIOTIC: Tributyrin is a special form of butyrate with a superior delivery of butyrate to help restore your gut lining, reduce occasional bloating, and support a balanced digestive system.
SUPERIOR TO SODIUM BUTYRATE: Unlike traditional butyrate supplements, such as sodium butyrate, which are largely absorbed in the stomach and small intestine, Tributyrin can travel further through the digestive system before being absorbed. This helps deliver butyrate where it's most useful, especially in the lower gut.
SUPPORTS GUT HEALTH & INTEGRITY: Supports gut lining health, helps the gut barrier stay strong, promotes a balanced microbiome, and aids in maintaining a healthy inflammatory response.
ENHANCED DELIVERY, SUPERIOR RESULTS: Tributyrin provides a smoother digestive experience, and ensures gradual, effective absorption, making it ideal for long-term use and sensitive individuals.
IDEAL FOR GUT RECOVERY & LONG-TERM SUPPORT: Whether you're addressing occasional bloating or focused on gut lining repair, this supplement fits seamlessly into wellness routines focused on digestive and microbiome health.

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8.1

Doctor's BEST

Doctor's BEST High Absorption Postbiotic Butyrate Featuring Corebiome, Gut & Immune Health, Non-GMO, Gluten Free, Soy Free, Vegan, 30 Liquid Veggie Caps

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Main Highlights

DOCTOR'S BEST HIGH ABSORPTION POSTBIOTIC BUTYRATE - featuring Corebiome is designed to provide a direct fuel source to colon cellssimilar to the fiber found in vegetables, to help maintain a healthy gut lining.*
POWERFUL POSTBIOTIC - also nurtures gut bacteria that actively supports a balanced microbiome by promoting healthy digestion, easing discomfort in the stomach, and boosting the immune system by maintaining optimal colon health.*
GUT LINE BARRIER - Gut lining prevents harmful substances from entering the bloodstream, while allowing the absorption of essential nutrients. Postbiotics helps to prevent the leakage of undigested food particles into the bloodstream.*
CLINICALLY TESTED - CoreBiome is a patented postbiotic, a Butyrate compound, intended to pass through the stomach and small intestine to bring support to the colon.* Vegetables ferment in colon to produce butyrate, CoreBiome is bioavailable butyrate.
ABOUT US: Supporting a healthy lifestyle for over 35 years. Founded by a physician and rooted in the science of nutrition, we believe better living begins with good nutrition, and good nutrition starts with sound science.

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8.1

DEVA

DEVA Vegan Tributyrin Supplement - Butyrate Precursor, Gut Barrier Support, Butyric Acid, 500 MG Vegan Capsules, Leaky Gut Support, Digestion, 90 Count

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Main Highlights

BUTYRATE PRECURSOR: Tributyrin is a well-studied precursor of the short-chain fatty acid Butyrate, which is produced in the human body when good bacteria break down the dietary fiber in the colon.
500 MG TRIBUTYRIN PER CAP: This supplement is made from non-animal sources through a special manufacturing process formulated to provide you with 500 mg of 100% vegan and vegetarian tributyrin per capsule.
GUT BARRIER SUPPORT: Butyrate appears to be involved in bowel function, water and sodium absorption in the intestines, and the maintenance of the gut's protective mucus layer.
GLUTEN FREE CAPSULES: Deva Tributyrin supplement does not contain dairy, gluten, salt, soy, sugar, wheat, or yeast.
CERTIFIED VEGAN: Our tributyrin butyrate precursor for women and men is 100% animal-free, vegetarian, and vegan certified by the Vegan Society.

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Our Best Overall Choice

Best Choice

9.7

Tesseract Medical Research

Tesseract Medical Research ProButyrate Gut Health Supplement, Butyric Acid Complex, Gastrointestinal Support Supplement, Helps Restore Balance to Stabilize Gut Microbiome, 600mg, 120 Capsules

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Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Revolutionary Digestive Health Supplement: ProButyrate is formulated with Butyric Acid in a sustained-release format, unlike other supplements that use Butyric salts, such as Sodium Butyrate. This palatable butyric acid supplement helps promote a healthy gut*
Maximum Absorption for Gut Health Support: Butyric acid is a short-chain fatty acid that supports the health of the gastrointestinal tract.* Insufficient natural production of this important fatty acid often leads to unpleasant adverse digestive conditions
Unrivalled Delivery: Tesseracts proprietary nano-molecular delivery science results in optimal absorption and bioavailability at micro-doses. A ground-breaking transport and time-release system that enables you to receive the full health benefits from your dietary supplements
Radically Advanced Formulation: Our CyLoc technology encases every nano-molecule of active ingredient in a unique carrier, and pairs it with the DexKey release agent. This allows for maximum absorption and efficacy of natural clinically researched nutrients
The Power of Tesseract: Tesseract Medical Research uses advanced scientific technology to make potent, breakthrough dietary supplements and medical foods to support optimum neurological, musculoskeletal, immune, and GI health.* Revolutionize your health with the full impact of clinically researched nutrients

Show Price

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