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10 Best Best Artificial Tears of 2025

Tested and Reviewed: Top 10 Best Artificial Tears deals with expert ratings from 8.1 to a perfect 10

March 2026 Edition

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1

Editor's Choice

9.7

Refresh Tears, Lubricant Eye Drops, 2 Bottles .5 fl oz (15 ml)

Refresh

Refresh Tears, Lubricant Eye Drops, 2 Bottles .5 fl oz (15 ml)

Editor's bottom line:

“This best artificial tears is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

IMMEDIATE DRY EYE RELIEF: Quickly alleviates dryness, irritation, and discomfort by replenishing moisture to the eyes.
MIMICS NATURAL TEARS: Formulated to closely resemble natural tears, providing soothing and effective hydration.
CONTACT LENS COMPATIBLE: Safe for use with contact lenses, making it convenient for individuals with corrective eyewear.
GENTLE DAILY FORMULA: Non-irritating and suitable for frequent use to maintain eye comfort throughout the day.
PROTECTIVE MOISTURE BARRIER: Helps shield eyes from further dryness and irritation caused by environmental factors.

Picked by 397 people today

2

9.5

Systane Ultra Lubricant Eye Drops, Artificial Tears for Dry Eye, Twin Pack, 10-mL Each

Systane

Systane Ultra Lubricant Eye Drops, Artificial Tears for Dry Eye, Twin Pack, 10-mL Each

Main Highlights

Dr Recommended Brand of Artificial Tears, packaging may vary
Extended Protection
Fast Long-Lasting Dry Eye Symptom Relief.Store at room temperature
Reduces both the signs and symptoms of dry eye
Quickly soothe irritated eyes wherever you are

3

9.5

REFRESH TEARS PF Preservative-Free Artificial Tears Lubricant Eye Drops, 0.33 fl oz (10 mL)

Refresh

REFRESH TEARS PF Preservative-Free Artificial Tears Lubricant Eye Drops, 0.33 fl oz (10 mL)

Main Highlights

ORIGINAL STRENGTH: Provides temporary relief for mild, occasional dry eye symptoms
FAST ACTING: Instantly lubricates and moisturizes
PRESERVATIVE-FREE: Made with zero preservatives to relieve mild symptoms of dry eyes including irritation, and discomfort
SOOTHING: Great for dry, sensitive eyes
SOFT-SQUEEZE MULTIDOSE BOTTLE: Features a double lockout system that keeps drops sterile
GENTLE: Safe to use as often as needed
RELIABLE PROTECTION: Active ingredients provide lasting lubrication for dry eyes

4

9.2

Refresh Plus Lubricant Eye Drops, Preservative-Free, 0.01 Fl Oz Single-Use Containers, 50 Count, Packaging May Vary

Refresh

Refresh Plus Lubricant Eye Drops, Preservative-Free, 0.01 Fl Oz Single-Use Containers, 50 Count, Packaging May Vary

Main Highlights

Original strength, preservative-free formula
Relieves mild symptoms of eye dryness
Instantly moisturizes and lubricates
Designed to act like your own natural tears
Great for sensitive eyes
Value size. 50 on-the go, single-use vials
Can be used after LASIK or other eye surgeries. Follow your eye doctor's instructions if you are using REFRESH RELIEVA PF after an eye surgery (e.g., LASIK) to relieve dryness and discomfort.
The selling brand in preservative-free artificial tears. REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.

5

9.0

Systane COMPLETE PF Multi-Dose Preservative Free Dry Eye Drops 0.34 Fl Oz, 2 count (pack of 1) (Packaging may vary)

Systane

Systane COMPLETE PF Multi-Dose Preservative Free Dry Eye Drops 0.34 Fl Oz, 2 count (pack of 1) (Packaging may vary)

Main Highlights

Nano-droplet technology features delivery of the eye drop over the entire eye surface for fast dry eye relief
Preservative-Free Eye Drop Solution: Ideal for users with sensitive eyes providing fast hydration and tear evaporation protection
Long-Lasting Relief: Systane Complete PF eye drops help aqueous deficient, evaporative/lipid deficient dry eye
Safe for Use with Contact Lenses: Systane eye drops are safe for use with soft contact lenses
8 Hours of Dry Eye Relief: From doctor's reccomended #1 Brand
Systane COMPLETE PF Eye Drops contains two 10mL bottles to use as needed to relieve, protect, and to lubricate dry eyes

6

8.8

TheraTears Dry Eye Therapy Lubricating Eye Drops for Dry Eyes, Preservative Free eye drops, 30 Single-Use Vials

TheraTears

TheraTears Dry Eye Therapy Lubricating Eye Drops for Dry Eyes, Preservative Free eye drops, 30 Single-Use Vials

Main Highlights

Dry eye relief without preservatives for sensitive eyes: TheraTears preservative-free lubricating eye drops in single-use vials provide immediate, long-lasting relief from dry eye symptoms
Instant hydration: TheraTears eye drops restore eyes natural balance and deliver fast hydration relief for dry eyes, because hydration is as essential for eye health as it is for the rest of the body
Electrolytes: TheraTears eye drops unique formula contains OxyLytes, the 5 vital electrolytes found in natural tears
Created by an ophthalmologist: The TheraTears formula was created by an ophthalmologist, following 18 years of research, for a one-of-a-kind eye drop
Doctor-recommended: TheraTears is a doctor-recommended brand (per ProVoice Survey data collected 9/1/23-8/31/24), created to bring balance and hydration to dry eyes; your purchase may be FSA/HSA eligible, check your health plan for details

7

8.6

REFRESH PLUS Lubricant Eye Drops Preservative-Free Artificial Tears, 0.01 fl oz (0.4 mL), 70 Single-Use Containers

Refresh

REFRESH PLUS Lubricant Eye Drops Preservative-Free Artificial Tears, 0.01 fl oz (0.4 mL), 70 Single-Use Containers

Main Highlights

LASTING RELIEF: Original strength lubricating formula soothes mild symptoms of eye dryness
PRESERVATIVE-FREE: Made with zero preservatives to relieve mild symptoms of dry eyes including burning, irritation, and discomfort
FAST ACTING: Instantly moisturizes and lubricates
RELIABLE PROTECTION: Active ingredients provide lasting lubrication for dry eyes
GENTLE: Safe to use as often as needed. Great for dry, sensitive eyes
VALUE SIZE: 70 on-the-go, single-use vials
CAN BE USED AFTER LASIK OR OTHER EYE SURGERIES: Follow your eye doctor's instructions if you are using REFRESH PLUS after an eye surgery (e.g., LASIK) to relieve dryness and discomfort.

8

8.3

TheraTears Extra Dry Eye Drops, Twin Pack, 2 Bottles x 0.5 fl oz (Pack of 1)

TheraTears

TheraTears Extra Dry Eye Drops, Twin Pack, 2 Bottles x 0.5 fl oz (Pack of 1)

Main Highlights

Immediate dry eye relief: TheraTears EXTRA Dry Eye Therapy lubricating eye drops provide immediate relief from dry eye symptoms; this formula delivers EXTRAordinary relief with up to 12 hours of hydrating comfort
Instant hydration: TheraTears EXTRA eye drops restore eyes natural balance and deliver fast hydration relief for dry eyes, because hydration supports dry eye health
Electrolytes: TheraTears eye drops unique formula contains OxyLytes, the 5 vital electrolytes found in natural tears
Created by an ophthalmologist: The TheraTears formula was created by an ophthalmologist, following 18 years of research, for a one-of-a-kind eye drop
Doctor-recommended: TheraTears is a doctor-recommended brand (per ProVoice Survey data collected 9/1/23-8/31/24), created to bring balance and hydration to dry eyes; your purchase may be FSA/HSA eligible, check your health plan for details

9

8.1

Refresh RELIEVA PF Xtra Preservative-Free Artificial Tears Lubricant Eye Drops, 0.33 fl oz (10 mL), 1 Count

Refresh

Refresh RELIEVA PF Xtra Preservative-Free Artificial Tears Lubricant Eye Drops, 0.33 fl oz (10 mL), 1 Count

Main Highlights

WORKS FAST: Preservative-free moisturizing relief for dry, sensitive eyes
ADVANCED FORMULATION: Innovated with moisture-locking technology. Enriched with hyaluronic acid and the antioxidant trehalose (inactive ingredients)
SOOTHING: Provides soothing hydration for mild to moderate symptoms of eye dryness
RELIABLE PROTECTION: Active ingredients provide lasting lubrication for dry eyes
SOFT-SQUEEZE MULTIDOSE BOTTLE: Features a double lockout system that keeps drops sterile
GENTLE: Safe to use as often as needed for dry, sensitive eyes
CONVENIENT: Patented multidose bottle keeps drops sterile and delivers a consistent drop every time

Our Best Overall Choice

9.7

Refresh Tears, Lubricant Eye Drops, 2 Bottles .5 fl oz (15 ml)

Refresh

Refresh Tears, Lubricant Eye Drops, 2 Bottles .5 fl oz (15 ml)

Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

IMMEDIATE DRY EYE RELIEF: Quickly alleviates dryness, irritation, and discomfort by replenishing moisture to the eyes.
MIMICS NATURAL TEARS: Formulated to closely resemble natural tears, providing soothing and effective hydration.
CONTACT LENS COMPATIBLE: Safe for use with contact lenses, making it convenient for individuals with corrective eyewear.
GENTLE DAILY FORMULA: Non-irritating and suitable for frequent use to maintain eye comfort throughout the day.
PROTECTIVE MOISTURE BARRIER: Helps shield eyes from further dryness and irritation caused by environmental factors.

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Special Amazon deal ends in:

Refresh Tears, Lubricant Eye Drops, 2 Bottles .5 fl oz (15 ml)

Special Amazon deal ends in: