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10 Best Best Artificial Tears of 2025

Tested and Reviewed: Top 10 Best Artificial Tears deals with expert ratings from 8.1 to a perfect 10

September 2025 Edition

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1

Editor's Choice

9.7

Save 28%

Refresh Optive MEGA-3 Lubricant Eye Drops Preservative-Free Artificial Tears, 0.01 fl oz (0.4 mL), 60 Single-Use Containers

Refresh

Refresh Optive MEGA-3 Lubricant Eye Drops Preservative-Free Artificial Tears, 0.01 fl oz (0.4 mL), 60 Single-Use Containers

Editor's bottom line:

“This best artificial tears is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

FAST-ACTING: Rapid relief to comfort dry, irritated eyes
LASTING RELIEF: Soothes and prevents further irritation
TRIPLE-ACTION FORMULA: Lubricates, hydrates, and protects tears from evaporating
PRESERVATIVE-FREE: Enhanced with antioxidants and plant-based Flaxseed Oil (inactive ingredients) which contains omega-3s
ADVANCED HYDRATION: Innovated with patented HydroCell technology that enables rehydration
ON-THE-GO VIALS: 60 sterile single-use vials per carton that are easy and safe to use as often as needed
TRUSTED: From the #1 doctor-recommended preservative-free brand with over 35 years of experience (Data on file, AbbVie, Inc. REF113774)
FSA & HSA ELIGIBLE: Your pre-tax dollars may cover this product as an out-of-pocket expense depending on your plan

Picked by 186 people today

2

9.5

Save 21%

Systane Ultra Lubricant Eye Drops, 60 Count (Pack of 1), (Packaging may vary)

Systane

Systane Ultra Lubricant Eye Drops, 60 Count (Pack of 1), (Packaging may vary)

21% OffFree Shipping

Main Highlights

#1 Dr Recommended Brand of Artificial Tears*
Extended Protection
Fast Long-Lasting Dry Eye Symptom Relief
Reduces both the signs and symptoms of dry eye
Single-Use Convenience. Store at room temperature

3

9.5

Refresh Plus Lubricant Eye Drops, Preservative-Free, 0.01 Fl Oz Single-Use Containers, 50 Count, Packaging May Vary

Refresh

Refresh Plus Lubricant Eye Drops, Preservative-Free, 0.01 Fl Oz Single-Use Containers, 50 Count, Packaging May Vary

Main Highlights

Original strength, preservative-free formula
Relieves mild symptoms of eye dryness
Instantly moisturizes and lubricates
Designed to act like your own natural tears
Great for sensitive eyes
Value size. 50 on-the go, single-use vials
Can be used after LASIK or other eye surgeries. Follow your eye doctor's instructions if you are using REFRESH RELIEVA PF after an eye surgery (e.g., LASIK) to relieve dryness and discomfort.
The selling brand in preservative-free artificial tears. REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.

4

9.2

Save 32%

Refresh RELIEVA PF Xtra Preservative-Free Artificial Tears Lubricant Eye Drops, 0.33 fl oz (10 mL)

Refresh

Refresh RELIEVA PF Xtra Preservative-Free Artificial Tears Lubricant Eye Drops, 0.33 fl oz (10 mL)

32% OffFree Shipping

Main Highlights

WORKS FAST: Quick, soothing relief for dry eyes that lasts
ADVANCED FORMULA: Innovated with moisture-locking technology and enriched with the antioxidant Trehalose (inactive ingredient)
PRESERVATIVE-FREE: Great for sensitive eyes
SOFT SQUEEZE MULTIDOSE BOTTLE: Features a double lockout system that keeps drops sterile
TRUSTED: From the #1 doctor-recommended preservative-free brand with 35+ years of experience (Data on file, AbbVie, Inc. REF-113774)
FSA & HSA ELIGIBLE: Your pre-tax dollars may cover this product as an out-of-pocket expense depending on your plan

5

9.0

Save 41%

Systane Ultra Lubricant Eye Drops, Artificial Tears for Dry Eye, Twin Pack, 10-mL Each

Systane

Systane Ultra Lubricant Eye Drops, Artificial Tears for Dry Eye, Twin Pack, 10-mL Each

Main Highlights

#1 Dr Recommended Brand of Artificial Tears*, packaging may vary
Extended Protection
Fast Long-Lasting Dry Eye Symptom Relief.Store at room temperature
Reduces both the signs and symptoms of dry eye
Quickly soothe irritated eyes wherever you are

6

8.8

Save 6%

Refresh Tears, Lubricant Eye Drops, 2 Bottles .5 fl oz (15 ml)

Refresh

Refresh Tears, Lubricant Eye Drops, 2 Bottles .5 fl oz (15 ml)

6% OffFree Shipping

Main Highlights

IMMEDIATE DRY EYE RELIEF: Quickly alleviates dryness, irritation, and discomfort by replenishing moisture to the eyes.
MIMICS NATURAL TEARS: Formulated to closely resemble natural tears, providing soothing and effective hydration.
CONTACT LENS COMPATIBLE: Safe for use with contact lenses, making it convenient for individuals with corrective eyewear.
GENTLE DAILY FORMULA: Non-irritating and suitable for frequent use to maintain eye comfort throughout the day.
PROTECTIVE MOISTURE BARRIER: Helps shield eyes from further dryness and irritation caused by environmental factors.

7

8.6

Save 15%

TheraTears Dry Eye Therapy Lubricating Eye Drops for Dry Eyes, Preservative Free eye drops, 30 Single-Use Vials

TheraTears

TheraTears Dry Eye Therapy Lubricating Eye Drops for Dry Eyes, Preservative Free eye drops, 30 Single-Use Vials

15% OffFree Shipping

Main Highlights

IMMEDIATE DRY EYE RELIEF: TheraTears Lubricating Eye Drops provide immediate, long-lasting relief of dry eye symptoms
INSTANT HYDRATING EYE DROPS: TheraTears dry eye drops provide instant, fast silky hydration for tired, dry eyes
ELECTROLYTE FORMULA: These eye drops for dry eyes are formulated with the 5 vital electrolytes found in natural tears
PRESERVATIVE FREE EYE DROPS: These eye drops come in a single-use vial and are preservative free
CREATED BY AN OPHTHALMOLOGIST: TheraTears was created by an ophthalmologist after 18 years of research for a one-of-a-kind eye drop

8

8.3

Save 24%

Refresh Tears Lubricant Eye Drops Artificial Tears, 0.5 fl oz (15 mL), 1 Count

Refresh

Refresh Tears Lubricant Eye Drops Artificial Tears, 0.5 fl oz (15 mL), 1 Count

24% OffFree Shipping

Main Highlights

ORIGINAL STRENGTH: Provides temporary relief for mild, occasional dry eye symptoms
FAST-ACTING: Instantly lubricates and moisturizes
EASY TO USE: Apply 1-2 drops in the affected eye(s) as needed
TRUSTED: From the #1 doctor-recommended preservative-free brand with over 35 years of experience (Data on file, AbbVie, Inc. REF113774)
FSA & HSA ELIGIBLE: Your pre-tax dollars may cover this product as an out-of-pocket expense depending on your plan

9

8.1

Save 16%

Systane Ultra Lubricant Eye Drops,0.14 Fl Oz (Pack of 1)

Systane

Systane Ultra Lubricant Eye Drops,0.14 Fl Oz (Pack of 1)

16% OffFree Shipping

Main Highlights

Dr Recommended Brand of Artificial Tears
Extended Protection
Fast Long-Lasting Dry Eye Symptom Relief
Reduces both the signs and symptoms of dry eye
Quickly soothe irritated eyes wherever you are

Our Best Overall Choice

9.7

Refresh Optive MEGA-3 Lubricant Eye Drops Preservative-Free Artificial Tears, 0.01 fl oz (0.4 mL), 60 Single-Use Containers

Refresh

Refresh Optive MEGA-3 Lubricant Eye Drops Preservative-Free Artificial Tears, 0.01 fl oz (0.4 mL), 60 Single-Use Containers

Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

FAST-ACTING: Rapid relief to comfort dry, irritated eyes
LASTING RELIEF: Soothes and prevents further irritation
TRIPLE-ACTION FORMULA: Lubricates, hydrates, and protects tears from evaporating
PRESERVATIVE-FREE: Enhanced with antioxidants and plant-based Flaxseed Oil (inactive ingredients) which contains omega-3s
ADVANCED HYDRATION: Innovated with patented HydroCell technology that enables rehydration
ON-THE-GO VIALS: 60 sterile single-use vials per carton that are easy and safe to use as often as needed
TRUSTED: From the #1 doctor-recommended preservative-free brand with over 35 years of experience (Data on file, AbbVie, Inc. REF113774)
FSA & HSA ELIGIBLE: Your pre-tax dollars may cover this product as an out-of-pocket expense depending on your plan

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Special Amazon deal ends in:

Refresh Optive MEGA-3 Lubricant Eye Drops Preservative-Free Artificial Tears, 0.01 fl oz (0.4 mL), 60 Single-Use Containers

Special Amazon deal ends in: