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10 Best Artificial Tears Without Preservatives of 2025

Tested and Reviewed: Top 10 Artificial Tears Without Preservatives deals with expert ratings from 8.1 to a perfect 10

March 2026 Edition

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1

Editor's Choice

9.7

Refresh Tears PF Preservative-Free Artificial Tears Lubricant Eye Drops, 0.33 fl oz (10 mL)

Refresh

Refresh Tears PF Preservative-Free Artificial Tears Lubricant Eye Drops, 0.33 fl oz (10 mL)

Editor's bottom line:

“This artificial tears without preservatives is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

ORIGINAL STRENGTH: Provides temporary relief for mild, occasional dry eye symptoms
FAST-ACTING: Instantly lubricates and moisturizes
PRESERVATIVE-FREE: Great for sensitive eyes
SOFT SQUEEZE MULTIDOSE BOTTLE: Features a double lockout system that keeps drops sterile
TRUSTED: From the #1 doctor-recommended preservative-free brand with over 35 years of experience (Data on file, AbbVie, Inc. REF113774)
FSA & HSA ELIGIBLE: Your pre-tax dollars may cover this product as an out-of-pocket expense depending on your plan

Picked by 397 people today

2

9.5

Save 37%

Systane Hydration Multi-Dose Preservative-Free Eye Drops Dry Eye Relief Twin Pack (2x10ml)

Systane

Systane Hydration Multi-Dose Preservative-Free Eye Drops Dry Eye Relief Twin Pack (2x10ml)

Main Highlights

Hydrates fast and provides long-lasting relief for dry eyes
Preservative free eye drops
Contains hyaluronate for advanced hydration
Safe for use with all contact lenses
Extra moisturizing eye drops for sensitive eyes
Ideal for postsurgical patients, e.g. post-lasik or post cataract surgery with dry eye symptoms

3

9.5

Save 28%

TheraTears Dry Eye Therapy Lubricating Eye Drops for Dry Eyes, Preservative Free eye drops, 30 Single-Use Vials

TheraTears

TheraTears Dry Eye Therapy Lubricating Eye Drops for Dry Eyes, Preservative Free eye drops, 30 Single-Use Vials

Main Highlights

Dry eye relief without preservatives for sensitive eyes: TheraTears preservative-free lubricating eye drops in single-use vials provide immediate, long-lasting relief from dry eye symptoms
Instant hydration: TheraTears eye drops restore eyes natural balance and deliver fast hydration relief for dry eyes, because hydration is as essential for eye health as it is for the rest of the body
Electrolytes: TheraTears eye drops unique formula contains OxyLytes, the 5 vital electrolytes found in natural tears
Created by an ophthalmologist: The TheraTears formula was created by an ophthalmologist, following 18 years of research, for a one-of-a-kind eye drop
Doctor-recommended: TheraTears is a doctor-recommended brand (per ProVoice Survey data collected 9/1/23-8/31/24), created to bring balance and hydration to dry eyes; your purchase may be FSA/HSA eligible, check your health plan for details

4

9.2

Refresh Plus Lubricant Eye Drops, Preservative-Free, 0.01 Fl Oz Single-Use Containers, 50 Count, Packaging May Vary

Refresh

Refresh Plus Lubricant Eye Drops, Preservative-Free, 0.01 Fl Oz Single-Use Containers, 50 Count, Packaging May Vary

Main Highlights

Original strength, preservative-free formula
Relieves mild symptoms of eye dryness
Instantly moisturizes and lubricates
Designed to act like your own natural tears
Great for sensitive eyes
Value size. 50 on-the go, single-use vials
Can be used after LASIK or other eye surgeries. Follow your eye doctor's instructions if you are using REFRESH RELIEVA PF after an eye surgery (e.g., LASIK) to relieve dryness and discomfort.
The selling brand in preservative-free artificial tears. REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.

5

9.0

Save 12%

Systane COMPLETE PF Multi-Dose Preservative Free Dry Eye Drops 0.34 Fl Oz, 2 count (pack of 1) (Packaging may vary)

Systane

Systane COMPLETE PF Multi-Dose Preservative Free Dry Eye Drops 0.34 Fl Oz, 2 count (pack of 1) (Packaging may vary)

Main Highlights

Nano-droplet technology features delivery of the eye drop over the entire eye surface for fast dry eye relief
Preservative-Free Eye Drop Solution: Ideal for users with sensitive eyes providing fast hydration and tear evaporation protection
Long-Lasting Relief: Systane Complete PF eye drops help aqueous deficient, evaporative/lipid deficient dry eye
Safe for Use with Contact Lenses: Systane eye drops are safe for use with soft contact lenses
8 Hours of Dry Eye Relief: From doctor's reccomended #1 Brand
Systane COMPLETE PF Eye Drops contains two 10mL bottles to use as needed to relieve, protect, and to lubricate dry eyes

6

8.8

Save 28%

Refresh Optive Lubricant Eye Drops For Dry Eyes, Preservative-Free, 0.01 Fl Oz Single-Use Containers, 60 Count

Refresh

Refresh Optive Lubricant Eye Drops For Dry Eyes, Preservative-Free, 0.01 Fl Oz Single-Use Containers, 60 Count

Main Highlights

Dual-action formula lubricates and hydrates
Relieves mild symptoms of eye dryness
Works fast by delivering soothing moisture
Preservative-free for sensitive eyes
Value size: 60 on-the go, single-use vials
Can be used after LASIK or other eye surgeries. Follow your eye doctor's instructions if you are using REFRESH RELIEVA PF after an eye surgery (e.g., LASIK) to relieve dryness and discomfort.
The selling brand in preservative-free artificial tears; REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.

7

8.6

Save 18%

Refresh Optive MEGA-3 Lubricant Eye Drops Preservative-Free Artificial Tears, 0.01 fl oz (0.4 mL), 30 Single-Use Containers

Refresh

Refresh Optive MEGA-3 Lubricant Eye Drops Preservative-Free Artificial Tears, 0.01 fl oz (0.4 mL), 30 Single-Use Containers

Main Highlights

Preservative-free moisture-rich formula
Designed to relieve moderate symptoms of eye dryness.
Delivers advanced hydration and lubrication
Supports all three tear film layers
Helps prevent tears from evaporating
The only eye drop in the U.s. with Carboxymethylcellulose sodium, Glycerin, and Flaxseed Oil (an inactive ingredient)
Hydrocell technology enables hydration and maintains the volume of cells on the eye's surface
On-the-go single use vials
The #1 selling brand in preservative-free artificial tears; REFRESH Family of Products, Ipsos Healthcare, 2021 REFRESH ECP Recommendation Survey.

8

8.3

Save 47%

Systane Ultra PF Preservative-Free Eye Drops 10ml

Systane

Systane Ultra PF Preservative-Free Eye Drops 10ml

Main Highlights

Preservative-Free Lubricant Eye Drops
Fast-Acting Hydration and lasting dry eye relief
Moisture rich formula for sensitive eyes
Tear evaporation protection

9

8.1

Oasis TEARS PLUS Preservative-Free Lubricant Eye Drops, 30 containers, 0.3 ML/0.01 FL OZ

Oasis Tears

Oasis TEARS PLUS Preservative-Free Lubricant Eye Drops, 30 containers, 0.3 ML/0.01 FL OZ

Main Highlights

PRESERVATIVE-FREE FORMULAEach sterile single-use container delivers gentle hydration without preservatives.
CONVENIENT SINGLE-USE VIALS Designed for on-the-go relief and hygienic application.
SUPPORTS EYE COMFORT Maintains moisture on the ocular surface, suitable for dry environments, screen exposure, or relief of contact lens irritation.
OPTIMAL EYE LUBRICATIONEngineered with a viscosity that supports consistent dispensing and minimizes waste.
MANUFACTURED TO HIGH STANDARDSDeveloped by OASIS Medical, a trusted name in ophthalmic solutions, with a commitment to cGMP & ISO-aligned quality and safety.

Our Best Overall Choice

9.7

Refresh Tears PF Preservative-Free Artificial Tears Lubricant Eye Drops, 0.33 fl oz (10 mL)

Refresh

Refresh Tears PF Preservative-Free Artificial Tears Lubricant Eye Drops, 0.33 fl oz (10 mL)

Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

ORIGINAL STRENGTH: Provides temporary relief for mild, occasional dry eye symptoms
FAST-ACTING: Instantly lubricates and moisturizes
PRESERVATIVE-FREE: Great for sensitive eyes
SOFT SQUEEZE MULTIDOSE BOTTLE: Features a double lockout system that keeps drops sterile
TRUSTED: From the #1 doctor-recommended preservative-free brand with over 35 years of experience (Data on file, AbbVie, Inc. REF113774)
FSA & HSA ELIGIBLE: Your pre-tax dollars may cover this product as an out-of-pocket expense depending on your plan

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Special Amazon deal ends in:

Refresh Tears PF Preservative-Free Artificial Tears Lubricant Eye Drops, 0.33 fl oz (10 mL)

Special Amazon deal ends in: