10 Best Adjustable Ergonomic Mouse of 2025

Tested and Reviewed: Top 10 Adjustable Ergonomic Mouse deals with expert ratings from 8.1 to a perfect 10

July 2025 Edition

Editor's Choice

9.7

Logitech

Logitech Lift Vertical Ergonomic Mouse, Wireless, Bluetooth or Logi Bolt USB receiver, Quiet clicks, 4 buttons, compatible with Windows/macOS/iPadOS, Laptop, PC - Graphite

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Editor's bottom line:

“This adjustable ergonomic mouse is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Lift yourself up: When the desk life gets you down, lift yourself up with Logitech Lift Vertical Ergonomic Mouse - a great fit for small to medium right hands
Raise your hand into comfort: Rest on Lift upright mouse throughout the day, with a softly textured grip and snug thumb rest for level-above coziness
57 degrees of sooooothe: Lifts vertical shape helps wrists feel like ahhh at work, and promotes a more natural posture in the forearm, for day-long comfort and productivity
Relax into focus: Settle into work with a wireless computer mouse featuring easy-to-reach customizable buttons, whisper-quiet clicks, and a SmartWheel for smooth, seamless scrolling
Ergo-certified: Lift wireless vertical mouse has been designed, developed, tested, and approved according to criteria set out by leading ergonomists
Connect your way: Connect via Bluetooth Low Energy or Logi Bolt USB to Windows, macOS, iPadOS, Chrome OS, or Linux, and enjoy up to 2 years battery life
Plastic parts in Lift include certified post consumer recycled plastic (Graphite: 70%, Off-White and Rose: 54%(6)).

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Picked by 325 people today

9.5

ProtoArc

ProtoArc Wireless Trackball Mouse, EM01 NL Ergonomic Bluetooth Rollerball Thumb Rechargeable Computer Laptop Mouse, Adjustable Angle & 3 Device Connection for PC, Mac, Windows-Gray Ball

Free Shipping

Main Highlights

ERGONOMIC DESIGN for MORE COMFORT: Unique adjustable hinge allows you to customize the trackball angle from 0 to 20 degrees according to your needs, ensuring a more natural, comfortable hand position for all-day comfort
Precise Thumb Mouse: ProtoArc trackball mouse provides accurate and smooth tracking, allowing for easy navigation through documents and web pages. You no longer need to move your arm for the movement of the cursor. Your thumb will control the cursor instead via the trackball. It will effectively reduce fatigue and strain on your wrist and arm. More productive in the narrow space, such as the messy desktop, couch, bed etc. Note: this trackball mouse is not an ordinary traditional mouse.
Bluetooth & 2.4 G Wireless Connection: PLUG and PLAY. This trackball mouse has triple connection modes. You can control three devices at the same time, switch freely between PC, laptop and iPad with just one button to improve your efficiency. Compatible with Windows, Android, Mac OS PC Laptop Desktop etc
Rechargeable & Adjustable DPI: The bluetooth Trackball Mouse built-in rechargeable lithium battery. No need to change batteries. Please remember to turn it off if you do not use it for a long time. 5 DPI levels (200/400/800/1200/1600) allows you to change the cursor sensitivity easily and track more smoothly
Quiet Clicking: Smooth frosted surface and quiet clicks can bring a better user experience and free your worry about bothering others and keep you stay focused while working. Note: The middle scroll wheel is not silent. All the buttons are non-programmable and the back forward buttons are not compatible with Mac OS system
After using the trackball for a period of time, please clean the trackball and the three white rollers inside the hole to ensure that the trackball is always smooth. Note: When the computer is just started or a large application is running, it may also cause the trackball to not run smoothly
Warm Tips: Since it takes a learning curve to get used to the control method when using our trackball mouse for the first time, it may cause inconvenience to your mouse grip, you can experiment with different hand positions to find what is most comfortable for you. We recommend that you take 1-2 weeks to get used to it, as many users find that it will help reduce the pressure and pain on your wrist caused by long-term use of the mouse and improve comfort

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9.5

Save 25%

Lekvey

Lekvey Ergonomic Mouse, Vertical Wireless Mouse - Rechargeable 2.4GHz Optical Vertical Mice : 3 Adjustable DPI 800/1200/1600 Levels 6 Buttons, for Laptop, PC, Computer, Desktop, Notebook etc, Black

25% OffFree Shipping

Main Highlights

Ergonomic, Sleek and Rechargeable Design: Scientific ergonomic design encourages healthy neutral " handshake " wrist and arm positions for smoother movement and less overall strain
Multifunction and Convenient: Advanced " Page Back " and " Page Forward " functionality buttons provide convenience when web page browsing. 800 /1200/1600 DPI Levels -- Easily adjusts the sensitivity of the mouse
High-Capacity Rechargeable Battery: Built-in rechargeable battery. You no longer need to buy batteries, very convenient !! Easy To Use -- One nano USB receiver at the bottom of the mouse, Just Plug and Play
Widely Compatible: Widely compatible with Windows 2000 / XP / Vista / 7 / 8 / 10 / Linux. ** Note: Not compatible with Mac OS, Apple Products. ** Once you get used to the ergonomic mouse, you will love it so much
Lekvey Wireless Ergonomic Mouse: Revolutionize your work experience! Are you tired of using traditional mice that strain your wrist? Say goodbye to discomfort and hello to the Lekvey wireless carpal tunnel mouse! Designed with your ergonomic needs in mind, this innovative vertical ergonomic mouse offers a whole different level of comfort and efficiency

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9.2

SHARE SUNSHINE

Wireless Mouse Large Angle Adjustable Ergonomic Vertical Upright Carpal Tunnel Ergo Right Hand 6 buttons USB Optical Mice for PC Laptop Computer Macbook Gift,3600 DPI,Removable Palm Rest,RGB Light

Free Shipping

Main Highlights

Adjustable Angle Gradient: Customize your grip with the adjustable angle gradient feature, enabling you to find the perfect angle of this ergonomic wireless mouse for laptop pc computer desktop macbook that suits your hand and wrist for optimal comfort
Ergonomic Design for Comfort: This carpal tunnel mouse is designed to mimic the natural "handshake" position of the wrist and forearm to reduce muscle strain and wrist discomfort.This upright mouse large wireless mouse is ideal for users who spend long hours on their computers.The verical mouse for large hands enjoys one year worry free warranty
Advanced RGB Breathing Light & Removable Palm Rest: Set the mood right with customizable RGB lighting. The 'breathing' RGB light feature of wireless mouse with side buttons offers a dynamic light show right on your desk, creating an immersive gaming or work experience. Our cool led mouse light up mouse ergo wireless mouse large computer mouse for carpal tunnel comes with a removable palm rest, providing added comfort during long usage periods. It's designed to support your palm, reducing the chances of wrist pain and carpal tunnel
Wireless convenience & Easy set-up: Our vertical wireless mouse features a reliable, wireless connection with a range of up to 33 feet. Say goodbye to tangled cords and enjoy the freedom to work from wherever you choose.Our rgb wireless mouse ergonomic vertical mouse sideways mouse is easy to set up and use, with a plug-and-play design that requires no software or drivers. Simply connect the USB receiver to your computer and start using your vertical ergonomic mouse right away
Effortless precision: With adjustable DPI settings (1000/1600/2000/2400/3600), our wireless mouse ergonomic right hand vertical gaming mouse ergonomic mouse for mac guarantees smooth and precise tracking, catering to your individual preferences for an enhanced user experience.The back and forward buttons of lightweight wireless gaming mouse rgb wireless mouse long range wireless mouse travel mouse for laptop side scrolling mouse provide easy navigation
Universal compatibility: Our large wireless mouse for big hands is designed for seamless integration with Windows, macOS, and Linux operating systems, ensuring optimal performance across a wide range or devices
PERFECT GIFTThis full size wireless mouse with Removable Palm Rest is a Perfect christmas gift or other festival gift for men women mom dad daughter wife boyfriend grandparents grandma grandpa teenage boy girl sister teacher brother coworker neighbor husband.Good mothers day gifts for mom. Good teacher appreciation gifts.Perfect fathers day gifts for father.Perfect video editor gifts. Perfect graphic designer gifts. Good Back to school gift
Effortless precision, ergonomic design, and energy-saving features make our Large Ergonomic Vertical Mouse perfect for various applications such as office work, gaming, video editing, travel, graphic design,and many more. Elevate your productivity and experience with our versatile mouse

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9.0

Save 21%

TECKNET

TECKNET Ergonomic Mouse, Wireless Bluetooth Vertical Mouse, 4800 DPI Optical Tracking, 6 Adjustable DPI, Quiet Clicks, 2.4GHz with USB A Receiver, 6 Buttons, Wide Compatibility - Black

21% OffFree Shipping

Main Highlights

Seamless Switching Between Three DevicesThe ergonomic mouse features Bluetooth (5.0/3.0) and 2.4GHz USB A modes for connectivity. When connected via Bluetooth, The vertical mouse can effectively reduces the usage of your USB-A port (Bluetooth mode can connect to two devices simultaneously), which is convenient for devices without USB ports. To switch to 2.4GHz mode, simply plug in the USB receiver for quick connection without the need for additional software installation. With just a press of a button, you can easily switch between these two modes, enhancing your work efficiency (Note: The 2.4GHz receiver is built into the bottom of the mouse).
Higher DPI & 6 Adjustable LevelsThis vertical ergonomic mouse is equipped with a high-performance chip and features 6 adjustable DPI levels (4800/3200/2400/1600/1200/800) to meet your daily needs. wireless mouse upgraded technology allows this ergonomic mouse to operate smoothly on different types of surfaces. When changing the DPI, the light will flash, with the number of flashes corresponding to the DPI level.
Silent MouseThis computer mouse operates quietly, allowing for usage even in quiet environments like libraries. Additionally, the vertical mouse provides nearly silent clicks, helping avoid disturbances to others and ensuring your work or study remains undisturbed (Note: Only the left and right click buttons of the mouse are silent; other function buttons are not silent).
Ergonomic DesignThe wireless mouse's ergonomic design offers ultimate comfort by placing your palm at a near-vertical angle on the desktop, reducing pressure and pain on your wrist caused by prolonged inverted mouse usage (Note: Mouse is designed for right-handed use only).
Broad Compatibility and Low Battery WarningThe wireless computer mouse is compatible with various devices, including Windows, Mac, Chrome, and Linux laptops (side buttons are not compatible with macOS). Additionally, the bluetooth mouse for laptops enters power-saving mode (completely cutting off power) after being idle for about 8 minutes; you can awake it by pressing the right or left button. Note: We recommend using branded batteries to ensure the mouse's longevity. When the battery is low, the LED light will blink (2 AAA batteries not included).
36 MONTHS WARRANTYIf you encounter any problems in using the product, please feel free to contact our professional customer service team, enjoying TECKNET 36 Months Warranty (Registered Only).

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8.8

Save 7%

ProtoArc

ProtoArc Ergonomic Vertical Mouse, EM11 NL Bluetooth Rechargeable Wireless Mouse, 3 Multi-Device Connectivity for Computer/PC/Laptop, 2.4GHz Optical Mice for Windows, Mac OS, Black

7% OffFree Shipping

Main Highlights

Connect up to 3 Devices: This ergonomic wireless mouse features dual BT 5.0 and 2.4G USB connectivity modes for simultaneous connection of up to 3 different devices, and is compatible with Windows 8, Windows 10 or higher, Mac OS X 10.12 or higher, and Android 4.3 or higher
Rechargeable Ergonomic Mouse: The Bluetooth Vertical Mouse has a built-in 500mAh Li-Ion battery that can be conveniently recharged using the included Type-C cable
Ergonomic Vertical Design: The ergonomic mouse wireless keeps your wrist naturally straight, putting your forearm and wrist in a more natural and relaxed position, which can reduce overall fatigue compared to a standard mouse. Warm tips: We encourage you to relax your palm and hold the mouse naturally when using a vertical mouse
Warm tips: Since it takes a learning curve to get used to the shape when using our ergonomic mouse for the first time, it may cause inconvenience to your mouse grip, We recommend that you take 1-2 weeks to get used to it, as many users find that it will help reduce the pressure and pain on your wrist caused by long-term use of the mouse and improve comfort
Notes: We recommend that small to medium hands use our ergonomic vertical mouse. Please measure the size before ordering for a better fit and more comfort
Adjustable Dpi & High Performance: 1000/1600/2400 DPI levels provide higher sensitivity than standard optical mice for precise optical tracking; with the back and forward buttons, you can easily navigate websites and increase work efficiency. Note: All buttons are not programmable and the forward and back buttons are not compatible with Mac OS systems
Silent Clicking Sound: Our vertical mouse's whisper-quiet clicking helps you focus on what's important without any noise distractions. Therefore, it is perfect for shared workspaces such as offices or libraries

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8.6

Save 15%

TECKNET

TECKNET Ergonomic Mouse Wireless, Rechargeable Mouse Wireless Silent for Carpal Tunnel Right Hand, 2.4GHz USB Vertical Mouse Wireless for Laptop, 5 Adjustable 4800 DPI, Computer, MacBook, Desktop

15% OffFree Shipping

Main Highlights

Ergonomic Design: This ergonomic mouse promotes a natural wrist and arm position, minimizing hand fatigue from prolonged use. With a vertical layout, the vertical mouse aids in maintaining a comfortable posture, reducing shoulder and neck strain.
Long-Lasting & Rapid Charging: Equipped with a 600mAh battery, the ergonomic mouse wireless fully charges in 1.5 hours via Type-C (cable included). The vertical mouse delivers a 2-month runtime per charge(depending on the actual frequency of use).
Stable Wireless Vertical Mouse: 2.4 GHz technology ensures reliable 10m connectivity with zero interference. Plug-and-play via nano USB receiver (no drivers required). Ergonomic design maintains seamless productivity for office/remote professionals.
Silent Ergonomic Mouse Wireless: Silent-click tech eliminates noise in shared spaces (libraries/offices/homes). The vertical mouse is perfect for mobile workers in noise-sensitive environments, blending ergonomic comfort with wireless convenience. Note: The left and right click keys of this silent mouse are silent, and the other auxiliary keys are not silent.
Adjustable DPI Vertical Mouse: 5-step 4800-800 DPI adapts to tasks/habits. Tru-Wave optical tracking surpasses traditional mice with enhanced sensitivity, ensuring precision on multiple surfaces (excluding glass). Professional-grade responsiveness for graphic design/office workflows.
Wide Compatibility: 2.4GHz ergonomic mouse wireless ensures stable connectivity with USB-A devices (desktops/laptops/PCs). The vertical mouse seamlessly fits most computer models featuring USB-A port interfaces but excludes USB-C.
Power Saving Mode: The ergonomic mouse wireless Features an automatic sleep mode that automatically turns off and saves power after 8 minutes of inactivityclick any button to reactivate the vertical mouse.

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8.3

Save 10%

Nulea

Nulea M504 Wired Vertical Mouse, USB Ergonomic Optical Mouse with 4 Adjustable DPI, 11 RGB Backlight Modes, Compatible for Laptop, PC, Desktop, Mac, Grey

10% OffFree Shipping

Main Highlights

Advanced Ergonomic Design: Designed as 57 degree natural grip and keep your forearm muscle under natural position, making movement smoother and more flexible, reducing arm discomfort and effectively relieving wrist pain. Compared with traditional mouse, with unique ergonomic vertical mouse design, it may take a few days to get used to using it.
4 Adjustable DPI: Switch between DPI levels 800, 1200, 2400 and 3200 to adjust mouse responsiveness depending on your need and preference. Such as browsing the website, editing a diagram, drawing a picture, etc.
Plug and Play: The computer mouse no drivers required, plug and play wired mouse with 5.9ft cable and USB 2.0 interface, easily accessible with standard setup features. Portable and lightweight, very easy to carry and store. The lightweight design of the mouse helps to improve posture, reduce pressure on wrists and muscles, and bring you a more comfortable office experience.
11 RGB Lighting: The ergonomic mouse features RGB lighting that illuminates the outline of the mouse. Users can adjust the underglow depending on their preference to add a different working experience.
Featured Buttons: All buttons are easy to operate and won't twist your fingers. The Forward and Backward buttons are in an exact place and will help you greatly improve your efficiency. The button power is light and easy to click. Plus, metal non-slip scroll offers great durable quality. Note: Forward and Backward buttons are not compatible with MAC OS. All the buttons are non-programmable.

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8.1

Amazon Basics

Amazon Basics Computer Mouse Wireless, Ergonomic, 2.4 GHz Optical, DPI Adjustable, Compatible With PC, Mac, Laptop, Black

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Main Highlights

COMFORTABLE NAVIGATION: The wireless mouse is designed for smooth and easy computer interface navigation, and provides ease of use for prolonged periods without strain
EXCELLENT COMPATIBILITY: This ergonomic mouse for PC is compatible with Windows 7, 8, and 10
ROBUST WIRELESS CONNECTION: This laptop mouse has a stable 2.4 GHz connection that offers a 33-foot range to enable mobility and flexibility in your workspace setup
SECURE DATA TRANSMISSION: Featuring AES-128 encryption, this wireless computer mouse provides enhanced security for your data, delivering safe usage in any network environment
COMPACT DESIGN: This wireless mouse for laptops measures 4.1 x 2.9 x 1.5 inches, making it compact and easily portable

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Best Value

8.1

Save 45%

TECKNET

TECKNET Ergonomic Mouse, 4800 DPI Wireless Vertical Mouse, 5 Adjustable DPI Levels, 6 Buttons, 2.4G Silent Wireless Mouse for Laptop, PC, Chromebook, Mac - Black

45% OffFree Shipping

Main Highlights

Ergonomic DesignErgonomic mouse with Ergonomic Design, 52°angle to the tabletop. A natural handshake position effectively relieves pressure on the wrist and arm, preventing RSI syndrome caused by long-term mouse use. It is the ideal choice for prolonged office work
4800 High DPI5 adjustable DPI settings: 4800/3200/2400/1600/800, catering to different usage habits. Even if you're new to it, you can easily master the mouse. TECKNET ergonomic wireless mouse optical tracking provides the smoothest and most precise cursor control on most surfaces
Comfortable Shape for Most HandsThe shape is rounded and comfortable without sharp corners, suitable for most hand sizes. Unlike other mice, this mouse is suitable for most large, medium and small hand sizes, which reduces your concerns about size and provides a perfect using experience. Product size: 4.13in*2.55in
Quick Click ButtonsThe vertical mouse wireless added forward/back buttons provide convenience for web browsing. (Side buttons not supported on MAC OS).The features a silent click design, reducing click noise by over 99%, while ensuring optimal performance. This means you can feel every click but hardly hear any sound (note: forward/back buttons are not silent)
Stable Wireless ConnectionThe ergonomic mouse wireless uses 2.4GHz wireless technology, providing a stable and accurate connection without the need for any drivers. Simply plug the USB receiver into your laptop to start using the mouse, with a connection range of up to 32ft
Wide CompatibilityThe mouse ergonomic is compatible with a wide range of devices and can be used on desktops, laptops, PCs, MacBooks and other devices. Works with Windows 11/10/8/7/XP and Mac OS X10.4. It has a silent feature that allows it to be used in libraries, homes, offices, and other situations where low sound levels are required.

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Our Best Overall Choice

Best Choice

9.7

Logitech

Logitech Lift Vertical Ergonomic Mouse, Wireless, Bluetooth or Logi Bolt USB receiver, Quiet clicks, 4 buttons, compatible with Windows/macOS/iPadOS, Laptop, PC - Graphite

Free Shipping

Editor's bottom line:

“This is the best one we tested. In terms of quality, brand and price, we couldn't ask for more.”

Main Highlights

Lift yourself up: When the desk life gets you down, lift yourself up with Logitech Lift Vertical Ergonomic Mouse - a great fit for small to medium right hands
Raise your hand into comfort: Rest on Lift upright mouse throughout the day, with a softly textured grip and snug thumb rest for level-above coziness
57 degrees of sooooothe: Lifts vertical shape helps wrists feel like ahhh at work, and promotes a more natural posture in the forearm, for day-long comfort and productivity
Relax into focus: Settle into work with a wireless computer mouse featuring easy-to-reach customizable buttons, whisper-quiet clicks, and a SmartWheel for smooth, seamless scrolling
Ergo-certified: Lift wireless vertical mouse has been designed, developed, tested, and approved according to criteria set out by leading ergonomists
Connect your way: Connect via Bluetooth Low Energy or Logi Bolt USB to Windows, macOS, iPadOS, Chrome OS, or Linux, and enjoy up to 2 years battery life
Plastic parts in Lift include certified post consumer recycled plastic (Graphite: 70%, Off-White and Rose: 54%(6)).

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